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XB002 is a rationally designed, next-generation tissue factor (TF)–targeted antibody-drug conjugate (ADC) and our first biologic to advance to clinical trials.
Molecular structure shown is an artistic rendering
XB002 is a TF-ADC using a novel auristatin-linker payload that inhibits cell division by blocking tubulin polymerization.
Phase 1 dose-escalation and expansion study of XB002 as single-agent and combination therapy in inoperable locally advanced or metastatic solid tumors
Cohort Expansions
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This website includes information on investigational uses of compounds that have not been approved by FDA. Safety and efficacy of investigational compounds and/or investigational uses of approved products have not been established. The information presented should not be construed as a recommendation for use.
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