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XB002:
TF-Targeted
ADC

XB002 is a rationally designed, antibody-drug conjugate (ADC) and our first biologic to advance to clinical trials.
Molecular structure shown is an artistic rendering.
XB002 is an ADC shown in human xenograft models to target tissue factor (TF) and uses a novel auristatin-based microtubule inhibitor (MTI) payload.

Tissue factor overexpression in many solid tumors may contribute to tumor cell growth and survival, angiogenesis, and metastasis.
jewel hummingbird
Phase 1 dose-escalation and expansion study of XB002 as single-agent and combination therapy in inoperable locally advanced or metastatic tumors.
Cohort Expansions
For more information, visit
clinicaltrials.gov/study/NCT04925284
This website includes information on investigational uses of compounds that have not been approved by the U.S. Food and Drug Administration (FDA). Safety and efficacy of investigational compounds and/or investigational uses of approved products have not been established. The information presented should not be construed as a recommendation for use.
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