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Zanzalintinib (XL092)

Zanzalintinib is an oral multi-targeted tyrosine kinase inhibitor discovered and developed by Exelixis.
Molecular structure shown is an artistic rendering.
Zanzalintinib is designed to inhibit multiple receptor tyrosine kinases (RTKs), including VEGFR, MET, TAM kinases (AXL and MER), and other kinases implicated in the growth and spread of cancer.
Phase 1 dose-escalation and expansion study of zanzalintinib as single-agent and combination therapy in inoperable locally advanced or metastatic solid tumors.
Cohort Expansions
For more information, visit
stellarclinicaltrials.com/stellar-001
Phase 1b dose-escalation and expansion study of zanzalintinib in combination with immuno-oncology agents in unresectable advanced or metastatic solid tumors.
Cohort Expansions
For more information, visit
stellarclinicaltrials.com/stellar-002
Phase 1b/2 dose-finding and expansion study evaluating the safety and efficacy of zanzalintinib combined with either AB521 or AB521 plus nivolumab in advanced clear cell renal cell carcinoma or other advanced solid tumors.
Cohort Expansions
For more information, visit
clinicaltrials.gov/study/NCT06191796
Phase 3 randomized, open-label study of zanzalintinib with atezolizumab vs regorafenib in metastatic colorectal cancer.
For more information, visit
stellarclinicaltrials.com/stellar-303
Phase 3 randomized, open-label study of zanzalintinib with nivolumab vs sunitinib in advanced or metastatic non–clear cell renal cell carcinoma.
For more information, visit
stellarclinicaltrials.com/stellar-304
Phase 2/3, randomized, double-blind, controlled study of zanzalintinib in combination with pembrolizumab vs pembrolizumab in the first-line treatment of PD-L1 positive, recurrent or metastatic head and neck squamous cell carcinoma.
For more information, visit
clinicaltrials.gov/study/NCT06082167
This website includes information on investigational uses of compounds that have not been approved by the U.S. Food and Drug Administration (FDA). Safety and efficacy of investigational compounds and/or investigational uses of approved products have not been established. The information presented should not be construed as a recommendation for use.
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